This question struck me after I spent months trapped in a bizarre experimental phenomenon regarding material encapsulation. I was utterly confused, constantly doubting myself: should we just add anti-inflammatory components to every single implant to inhibit fibrosis-related factors?
Then today, I came across an article about mechanical forces and fibrosis, and it completely shocked me. I realized I had never once considered the impact of physical stretch or surgical sutures. For the past few months, it felt like I had a leaf over my eyes, blocking me from seeing the elephant in the room. I did know the adhesive model made using only sutures, but I attributed it solely to oxygen deficiency due to vascular blockage. It was only when I read that paper that I realized this model may also be taking advantage of mechanical force.